• Independently plan and execute experiments, analyze, and communicate results
• Actively apply new concepts and technologies
• Be proactive in solving technical problems through analyzing data and troubleshooting methods
• Perform a broad range of microscopy, histology, cell, and molecular biology techniques (e.g., confocal imaging, immunohistochemistry/immunofluorescence, in-situ hybridization, spatial transcriptomics, tissue/cell culture, flow cytometry, etc.)
• Develop microscopy and quantitative image analysis methods
• Provide support to in vivo preclinical studies to evaluate AAV vector tropism and biodistribution, and therapeutic rescue/safety, using molecular and histological analyses
• Develop research-grade assays (in-situ hybridization/RNA scope, immunohistochemistry/immunofluorescence, tissue microarray)
• Support and contribute to the development of AAV in vitro expression and functional assays
• Initiate and manage external research collaborations with contract research organizations and academic investigators in a diverse array of scientific disciplines
• Support and assist the members of the team

Skills: Microscopy Techniques, Image Analysis, Data Analysis, Problem Solving, Histology Methods, Molecular Biology, Assay Development, Preclinical Studies

• Perform image sensor and lens metrology
• Develop image sensor and optical correction algorithms
• Develop image statistics and QC analysis algorithms
• Image compression, debugging and analysis
• Design and develop de-mosaicking algorithms
• Analyze image sensor colorimetry and develop optimized color science
• Optimize algorithms for GPU and FPGA platforms
• Develop filtering, sampling and stabilization algorithms
• Analyze and determine system standards and test procedures
• Review invention disclosures for developed algorithms and work with patent attorneys to secure intellectual property
• Guide the creation of new image quality metrics, evaluation procedures, and invent novel image processing systems and methods
• Develop computer vision tools for image processing, feature extraction, object detection, classification, tracking, segmentation, camera calibration, optical flow, stereo, and structure from motion
• Design and implement multi-camera and sensor fusion algorithms

Skills: Sensor Metrology, Algorithm Development, Quality Control, Image Compression, Color Science, GPU Optimization, Computer Vision, Sensor Fusion

• Support the medical imaging team for both development and customer needs
• Providing excellent and responsive medical information for the global community regarding investigational and commercial products
• Provide expert interpretation of scans obtained in clinical trials
• Collaborate with Imaging Research and Development
• Providing imaging analysis expertise and making appropriate recommendations
• Anticipate the evolution of imaging and imaging applications and seek ways to position Avid to best evaluate the potential value of these directions
• Assist in developing, reviewing, and approving Phase 1-3 and post-market clinical imaging studies
• Lead community physicians’ training efforts for scan interpretation, including the development of training material
• Interface with scientific and educational organizations involved in clinical imaging
• Support review of data analysis and the development of slide decks and publications (abstracts, posters, manuscripts)
• Seek out opportunities to stay abreast of new developments in diagnostic imaging technology

Skills: Medical Imaging, Image Interpretation, Imaging Analysis, Clinical Trials, Physician Training, Data Review, Publication Development, Technology Evaluation

• Implements or modifies existing algorithms to analyze histopathology images and data
• Implements software in prototyping and commercial product development environments
• Collaborates with other members of a project team to meet defined scientific and technical goals/requirements
• Interacts in a multidisciplinary environment with internal and external stakeholders (e.g., pathologists, biochemists, instrumentation engineers, software engineers, and marketing representatives)
• Keeps up-to-date with technology advances and job training requirements in the medical device industry
• Identifies and documents Intellectual Property opportunities for technology and applications
• Presents results to project partners, collaboration partners within the Roche group, customers, and at scientific conferences
• Identifying and developing new and innovative imaging capabilities and methods to enable the discovery of novel aspects of condensate dynamics, biochemistry, and nucleic acid/protein interactions central to advancing drug discovery efforts
• Contributing to building an imaging infrastructure platform to enable robust and efficient condensate readouts in both in vitro and in vivo systems
• Expanding suite of analysis capabilities including the integration of machine learning algorithms
• Supporting project workstreams that are focused on integrating imaging with all stages of drug discovery including target ID and selection, hit generation, and lead characterization, and efforts to develop tools for compound and genetic screens
• Adopting and enabling various state-of-the-art imaging techniques, including single-molecule imaging
• Partnering with CROs and determining the most effective balance of internal and external resources
• Working cross-functionally with biology, chemistry and other disciplines to move projects and pipeline efforts forward

Skills: Algorithm Implementation, Software Development, Project Collaboration, Stakeholder Interaction, Technology Awareness, Intellectual Property, Imaging Innovation, Machine Learning

• Work in partnership with project teams across AZ therapy areas to understand project issues
• Analyse and report the data produced, with little or no guidance, clearly and concisely
• Lead the design of advanced molecular imaging endpoints
• Support safety and efficacy studies and provide advice on specific topics to the team
• Maintain knowledge internally and externally of new trends in molecular imaging technology, experimental techniques/equipment
• Introduce methods and instrumentation with the Integrated Imaging Sciences Leadership Team
• Manage portfolio support to ensure delivery to agreed timelines and quality standards
• Provide disciplinary scientific leadership and mentorship for less-experienced scientists
• Manage scientists from student and postdoc programmes
• Carry out research aligned to CPSS objectives with academic or cross-pharma pre-competitive groups and publish research papers and reviews in internationally recognised journals
• Support the department's leadership team in both the strategic vision for the department and the efficient and progressive running of the department

Skills: Data Analysis, Imaging Design, Safety Studies, Technology Awareness, Method Introduction, Portfolio Management, Scientific Leadership, Research Publication

• Hands-on experience with algorithm development for image or data analysis algorithms
• Experience in the design and development of analysis algorithms for biomedical image data
• Product development experience with a focus on data analysis
• Proven track record of publications and intellectual property generation from own work
• Experience working with Digital Pathology tools or Software
• Experience working with Medical devices
• Excellent skillsets in Python, C++, or MATLAB
• Good understanding of scientific principles
• Good analytical and mathematical skills
• Working knowledge and theoretical understanding of image analysis, pattern recognition, machine learning, computer vision, and data mining methods
• Extensive experience with commonly used Deep Learning models and frameworks (e.g., Pytorch, Fastai, TensorFlow)
• Understanding and following software engineering practices for prototyping and commercial product development in languages
• Good understanding of biomedical image data including pathology images
• Understanding of R&D work in a regulated industry

Qualifications: BS in Biomedical Engineering with 7 years of Experience

• Experience in microscopy, histology, cell biology, molecular biology, and immunology (industry or academic setting BR1, BR2 )
• Solid proficiency and demonstrated track record of fluorescent and brightfield microscopy, confocal microscopy, immunohistochemistry, multi-plex immunofluorescent labeling, in-situ hybridization and image analysis methods
• Familiarity with ocular anatomy and physiology
• Strong cell culture skills with a demonstrated track record such as sterile technique for handling and maintenance of mammalian cells, flow cytometry and cell-based assay development
• Experience with tissue explant cultures, primary cell lines, and/or iPS
• Experience with image analysis platforms (Image J, Halo)
• Demonstrated ability to work independently or in a team-oriented environment with moderate supervision
• Excellent data analysis skills and experience with a variety of scientific software applications (Microsoft Office, Prism, Geneious, Adobe Photoshop, Illustrator)
• Strong experimental design and demonstrable track record of solving technical problems through analyzing data and troubleshooting method issues
• Excellent communication, presentation, collaboration, time management, and organization skills
• Proven ability to work independently in a hands-on laboratory setting, self-motivated to learn and develop new techniques, perform multiple tasks simultaneously, keep accurate and timely records, follow instructions, and comply with company policies
• Able to be motivated to apply her/his skills to diverse projects and enjoy working in a fast-paced team environment
• Familiarity with drug product development, creating SOPs and GxP

Qualifications: BS in Bioinformatics with 9 years of Experience

• Research experience as a post-PhD in academic/non-academic healthcare organizations as an independent scientist
• Previous experience in leading radiochemistry and PET ligand development projects
• Good understanding of radiochemical method development and the Implementation/validation of new technologies
• Experience with the application of molecular imaging to study drug effects, biodistribution, and target engagement
• Excellent interpersonal skills and ability to work independently as well as in cross-functional teams with colleagues in multiple locations to build and maintain constructive working relationships
• Positive and collaborative team player with a willingness to improve and learn new skills
• Strong problem-solving and troubleshooting skills and strong capabilities in experimental design and execution
• Excellent presentation skills to report data clearly and concisely, with a clear understanding of its implications
• Proven track record of productivity including authorship in peer-reviewed scientific publications
• Excellent communication skills in English, both verbal and in writing
• Previous experience from the pharmaceutical industry
• Understanding of pharmaceutical discovery and development processes (from preclinical to clinical stages)

Qualifications: BS in Electrical Engineering with 8 years of Experience

• Proven track record of research accomplishments in the biomedical imaging field
• In vivo small animal handling skills such as inhalation anesthesia, IV and IP injections
• Familiarity with IACUC protocols/guidelines for the conduct of in vivo studies
• Experience/expertise with operating some of the following animal imaging systems: MRI, PET, SPECT, optical and/or CT
• Hands-on experience with animal MRI, optical and/or PET imaging technologies/systems 
• Experience with biomedical image processing and data analysis
• Strong computational skills for Python and MATLAB coding, and bio-image data analysis 
• Experience with immunofluorescence labeling, nanoparticles, MRI probes, and/or other bio-probes for preclinical experimentation
• Experience with handling radioactivity for preclinical experimentation
• Experience in cell/molecular biology and/or translational imaging biomarkers
• Experience with IHC analysis and other ex vivo/in vitro microscopy assays
• Excellent written and verbal communication skills
• Proven abilities to work in a team environment with high motivation, minimal supervision, and a strong work ethic

Qualifications: BS in Computational Biology with 9 years of Experience

• Able to process medical images using a wide variety of techniques
• Demonstrated creative thinking and problem-solving
• Ability to communicate work and results
• Ability to interface with Sponsors throughout the development process
• Must be independently motivated with a strong work ethic
• Must be interested and excited to solve challenging technical problems
• Experience with all or some of the following imaging modalities: uCT, X-Ray, PET/CT, US, and MRI
• Must be able to communicate well with technical scientists, management, and sponsors
• Should thrive on a high volume of exciting and challenging technical problems

Qualifications: BS in Data Science with 4 years of Experience