HISTOTECHNOLOGIST SKILLS, EXPERIENCE, AND JOB REQUIREMENTS

Published: Sep 11, 2025 - The Histotechnologist has experience working in CAP, JCAHO, AABB, or equivalent accredited histopathology laboratories under the supervision of board-certified pathologists or medical scientists. This role requires HTL (ASCP) certification, completion of a NAACLS-accredited HT program, and strong technical skills in IHC (antibody optimization, detection systems, troubleshooting artifacts), molecular assays (FISH, PCR, in-situ hybridization), and compliance with CLIA/CAP quality standards. The Histotechnologist also has the ability in workflow coordination, staff training, and efficient specimen prioritization while demonstrating strong troubleshooting and problem-solving skills in tissue preparation and staining.

Essential Hard and Soft Skills for a Standout Histotechnologist Resume
  • Tissue Processing
  • Microtomy Sectioning
  • H&E Staining
  • Frozen Sectioning
  • Immunohistochemistry Staining
  • Special Staining
  • Equipment Maintenance
  • Quality Control
  • Documentation Accuracy
  • Regulatory Compliance
  • Team Collaboration
  • Problem Solving
  • Time Management
  • Safety Compliance
  • Effective Communication
  • Staff Training
  • Work Prioritization
  • Adaptability
  • Independent Judgment
  • Procedure Improvement

Summary of Histotechnologist Knowledge and Qualifications on Resume

1. BS in Biomedical Sciences with 2 years of Experience

  • Experience in Histology and meet all licenses necessary for Histology.
  • ASCP Histology certification or other relevant Histology certifications.
  • Ability to meet CLIA requirements.
  • Experience with routine histology procedures and equipment.
  • Previous immunohistochemistry experience.
  • Comfortable embedding both large and small specimens.
  • Ability to accurately read all labels and documents.
  • Ability to work independently within a team and strong attention to detail.
  • Experience working in a high-volume laboratory environment.
  • Familiarity with laboratory SOPs and safety protocol.
  • Skilled in handling multiple specimens efficiently while meeting turnaround times.

2. BS in Histotechnology with 4 years of Experience

  • Possess HT (ASCP) or HTL (ASCP).
  • Proven Histology work experience.
  • Working knowledge of and can perform IHC testing, preferably with a qualification in Immunohistochemistry (QIHC) obtained through ASCP.
  • Knowledge of in-situ hybridization (ISH) procedures.
  • Ability to meet all requirements as outlined in the corporate Minimum Qualifications for Histotechnician SOP.
  • Knowledge of computer skills in word processing, Excel, and database entry.
  • Skilled in paraffin embedding and cutting high-quality tissue sections, including difficult tissue types.
  • Experience performing and interpreting a wide range of histochemical stains (e.g., PAS, Trichrome, GMS, Ziehl-Neelsen).
  • Skilled in routine care, calibration, and troubleshooting of histology instruments (microtomes, cryostats, tissue processors, stainers).
  • Ability to analyze test results, spot inconsistencies, and make sound decisions under pressure.
  • Strong ability to maintain accurate records, label specimens correctly, and manage multiple cases without error.

3. BS in Molecular Biology with 5 years of Experience

  • Experience in a histology laboratory with competency in microtomy/cutting, embedding, and routine staining.
  • ASCP Board of Certification, to include Histotechnician (HT), American Society for Clinical Pathology (ASCP), or Histotechnologist (HTL), ASCP.
  • Working knowledge of Immunohistochemistry (IHC) and/or In-Situ Hybridization (ISH) Techniques.
  • Competency in producing rapid frozen sections for intraoperative consultations.
  • Skilled in performing and troubleshooting a wide range of histochemical special stains (e.g., PAS, GMS, Trichrome).
  • Familiarity with CAP, CLIA, or Joint Commission requirements, and experience supporting audits/inspections.
  • Ability to integrate and professionally apply feedback.
  • Ability to prioritize and drive results with a high emphasis on quality.
  • Ability to work independently and within a team environment.
  • Strong interpersonal communication skills and the ability to maintain open communication with internal employees, managers, and customers.
  • Ability to multitask and be flexible with tasks and schedules, with attention to detail.
  • Strong computer skills.

4. BS in Biochemistry with 3 years of Experience

  • Experience as a Histotechnician with HT (ASCP) or HTL (ASCP).
  • Knowledge of Tissue Processing Techniques.
  • Ability to evaluate tissue quality, identify artifacts, and perform microscopic checks for diagnostic accuracy.
  • Experience with digital data entry, specimen tracking, and maintaining accurate records.
  • Understanding of CLIA, CAP, OSHA, and other laboratory regulations, plus adherence to biosafety protocols.
  • Experience performing and documenting QC checks to ensure reliability and consistency of test results.
  • Ability to stay focused under stressful conditions and the ability to receive constructive feedback.
  • A positive attitude and can respond to unexpected change without loss of motivation.
  • Can work with a team with diverse backgrounds.
  • Self-discipline, ability for tolerance and stamina, and hand-eye coordination.
  • Ability to maintain repetitive motion tasks.

5. BS in Biology with 1 year of Experience

  • Working knowledge of OSHA requirements concerning chemical hygiene and bloodborne pathogens.
  • Histotechnician (HT) or Histotechnologist (HTL) certification or certification eligible by the American Society for Clinical Pathology (ASCP).
  • Strong critical thinking skills, decisive judgment, and the ability to work with minimal supervision.
  • Must be able to work in a highly technical, stressful environment and take appropriate action.
  • Prior hands-on laboratory experience from an accredited Histotechnology school or prior histology laboratory experience.
  • Manual dexterity and visual acuity when handling specimens, slides, and utilizing instrumentation.
  • Ability to safely handle potentially infectious patient specimens, carcinogenic substances, odorous, and other hazardous materials to which they may be exposed.
  • Must have the ability to sit, stand, or walk extensively.
  • Able to follow standard precautions using personal protective equipment.

6. BS in Microbiology with 6 years of Experience

  • Histotechnologist (HTL) certification from the American Society for Clinical Pathology (ASCP).
  • Experience in a histopathology laboratory in the U.S., Canada, or a CAP/The Joint Commission (JCAHO)/AABB accredited laboratory.
  • Experience must be under the supervision of a pathologist (certified by the American Board of Pathology in Anatomic Pathology) or an appropriately board-certified medical scientist.
  • Successful completion of a NAACLS-accredited HT program.
  • Clinical laboratory experience post-training.
  • Hands-on experience with IHC, including antibody optimization, detection systems, and troubleshooting staining artifacts.
  • Exposure to molecular assays relevant to histology (e.g., FISH, PCR-based tissue testing, in situ hybridization).
  • Familiarity with CLIA, CAP inspection checklists, and internal quality control practices beyond basic lab operations.
  • Experience mentoring junior staff, training students, or coordinating workflow in a histology lab environment.
  • Ability to prioritize and balance multiple specimens, stains, and processes efficiently under tight turnaround times, with attention to detail.
  • Strong troubleshooting mindset to quickly address issues with equipment, tissue preparation, or staining results.

7. BS in Medical Laboratory Science with 7 years of Experience

  • Progressive acceptable clinical laboratory experience, i.e., specialist certification, documented increasing clinical laboratory responsibility, and/or documented continuing education in a chosen clinical specialty area.
  • HTL (ASCP), IHC (ASCP), HT (ASCP), NCA (NCS), and other acceptable certificates/licensures or related experience under a board-certified pathologist.
  • Experience in an accredited anatomic pathology laboratory.
  • Experience in Immunohistochemistry and the performance of IHC staining techniques.
  • Thorough knowledge of the theory and principles of Immunohistochemistry.
  • Working knowledge of diluting concentrated antibodies.
  • Documented experience in research methods morphological investigation, with exposure to a broad range of techniques.
  • Progressive, acceptable anatomical laboratory experience.
  • Ability to provide a timely communication link between staff and leadership.
  • Demonstrated technical/clinical expertise.
  • Good communication skills and superb attention to detail.
Relevant Information
Clinical Laboratory Scientist Skills, Experience, and Job Requirements
Cytotechnologist Skills, Experience, and Job Requirements
Histology Technician Skills, Experience, and Job Requirements